Motif ID: FOX{C1,C2}.p2

Z-value: 0.725


Transcription factors associated with FOX{C1,C2}.p2:

Gene SymbolEntrez IDGene Name
FOXC1 2296 forkhead box C1
FOXC2 2303 forkhead box C2 (MFH-1, mesenchyme forkhead 1)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXC1chr6_+_15565430.204.5e-01Click!
FOXC2chr16_+_85158357-0.155.9e-01Click!


Activity profile for motif FOX{C1,C2}.p2.

activity profile for motif FOX{C1,C2}.p2


Sorted Z-values histogram for motif FOX{C1,C2}.p2

Sorted Z-values for motif FOX{C1,C2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{C1,C2}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr20_+_17628592 0.911 NM_001014977
NM_178477
BANF2

barrier to autointegration factor 2

chr6_-_169392771 0.884


chr11_+_110890719 0.799 NM_001100388
NM_207430
C11orf88

chromosome 11 open reading frame 88

chr2_+_178893216 0.746 NM_145739
OSBPL6
oxysterol binding protein-like 6
chr17_-_45626364 0.608


chr3_+_120375053 0.597 NM_006952
UPK1B
uroplakin 1B
chr15_+_55671393 0.578 NM_001018090
NM_001018091
NM_001018100
NM_152451
GCOM1



GRINL1A complex locus



chr6_-_33879734 0.559 NM_001040109
NM_001184698
NM_002418
MLN


motilin


chr17_-_45620313 0.535


chr5_+_140690387 0.532 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr11_+_61714263 0.525 NM_006552
SCGB1D1
secretoglobin, family 1D, member 1
chr16_+_55156461 0.523 NM_032935
MT4
metallothionein 4
chr3_+_115099007 0.516 NM_001172105
GRAMD1C
GRAM domain containing 1C
chr20_-_60435983 0.505 NM_080833
C20orf151
chromosome 20 open reading frame 151
chr6_+_47732181 0.504 NM_153839
GPR111
G protein-coupled receptor 111
chr7_-_98643024 0.498 NM_001145715
KPNA7
karyopherin alpha 7 (importin alpha 8)
chr7_-_87694218 0.495 NM_198901
SRI
sorcin
chr7_-_55897938 0.492 NM_207366
SEPT14
septin 14
chr2_-_37269193 0.482 NM_001032377
SULT6B1
sulfotransferase family, cytosolic, 6B, member 1
chr10_-_13316333 0.476 NM_145314
UCMA
upper zone of growth plate and cartilage matrix associated
chr6_-_159386007 0.476 NM_054114
NM_138810
NM_152133
TAGAP


T-cell activation RhoGTPase activating protein


chr17_-_61655915 0.433 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr19_-_9087438 0.408 NM_001005192
OR7G1
olfactory receptor, family 7, subfamily G, member 1
chr1_+_198263352 0.405 NM_003822
NM_205860
NR5A2

nuclear receptor subfamily 5, group A, member 2

chr2_+_234286376 0.401 NM_019078
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A5
chr6_-_138862271 0.385 NM_001144060
NHSL1
NHS-like 1
chr4_-_38534802 0.384 NM_006068
TLR6
toll-like receptor 6
chr2_+_95621492 0.380 NM_138800
TRIM43
tripartite motif containing 43
chr2_+_149895274 0.378 NM_194317
LYPD6
LY6/PLAUR domain containing 6
chr11_-_61823078 0.372 NM_206998
SCGB1D4
secretoglobin, family 1D, member 4
chr1_+_158352143 0.355 NM_000702
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr2_-_216008689 0.355 FN1
fibronectin 1
chr2_+_234302511 0.349 NM_019093
UGT1A3
UDP glucuronosyltransferase 1 family, polypeptide A3
chr19_+_6981593 0.348 NM_001136507
MBD3L5
methyl-CpG-binding domain protein 3-like 5-like
chr5_+_150000394 0.344 NM_001109974
NM_007286
SYNPO

synaptopodin

chr6_-_41230003 0.341 NM_178174
TREML1
triggering receptor expressed on myeloid cells-like 1
chr6_+_31016755 0.337 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr22_+_16423147 0.336 NM_031481
SLC25A18
solute carrier family 25 (mitochondrial carrier), member 18
chr16_-_21130368 0.335 NM_003460
ZP2
zona pellucida glycoprotein 2 (sperm receptor)
chr5_+_38481392 0.332 NM_182801
EGFLAM
EGF-like, fibronectin type III and laminin G domains
chr7_+_129693938 0.325 NM_001869
CPA2
carboxypeptidase A2 (pancreatic)
chr7_+_147667461 0.317 CNTNAP2
contactin associated protein-like 2
chr17_-_39191658 0.312 NM_025237
SOST
sclerostin
chr1_-_197173159 0.303 LOC100131234
familial acute myelogenous leukemia related factor
chr1_+_111573855 0.303 NM_001025199
CHI3L2
chitinase 3-like 2
chr3_-_150578023 0.301 TM4SF1
transmembrane 4 L six family member 1
chr9_+_674193 0.299


chr1_-_166965034 0.298 NM_001937
DPT
dermatopontin
chr2_+_73973600 0.292 NM_001615
ACTG2
actin, gamma 2, smooth muscle, enteric
chr8_-_109868945 0.288 NM_153015
TMEM74
transmembrane protein 74
chr2_+_73973640 0.281 ACTG2
actin, gamma 2, smooth muscle, enteric
chr4_+_159662349 0.279 NM_021634
RXFP1
relaxin/insulin-like family peptide receptor 1
chr1_+_24518501 0.272 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr18_-_54447168 0.269 NM_052947
ALPK2
alpha-kinase 2
chr10_-_27097782 0.267 ABI1
abl-interactor 1
chr20_+_9146036 0.266 NM_182797
PLCB4
phospholipase C, beta 4
chr14_+_22059212 0.262


chr22_+_29333069 0.262 NM_000355
NM_001184726
TCN2

transcobalamin II

chr5_+_35892747 0.259 NM_002185
IL7R
interleukin 7 receptor
chr4_-_152366970 0.259 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr2_+_69055208 0.256 NM_019617
GKN1
gastrokine 1
chr3_+_137224266 0.249 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr12_-_25597444 0.244 NM_152590
NM_001145728
NM_001145729
IFLTD1


intermediate filament tail domain containing 1


chr10_+_96512447 0.242 NM_000769
CYP2C19
cytochrome P450, family 2, subfamily C, polypeptide 19
chr14_+_50096603 0.242 ATL1
atlastin GTPase 1
chr3_+_195336625 0.238 NM_005524
HES1
hairy and enhancer of split 1, (Drosophila)
chr3_+_195336631 0.230 HES1
hairy and enhancer of split 1, (Drosophila)
chr19_-_40746399 0.228 NM_000704
ATP4A
ATPase, H+/K+ exchanging, alpha polypeptide
chr2_+_33213111 0.225 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr3_+_186529376 0.223 MAP3K13
mitogen-activated protein kinase kinase kinase 13
chr11_-_8789457 0.223 NM_139157
ST5
suppression of tumorigenicity 5
chr2_+_73864823 0.222 NM_001080474
C2orf78
chromosome 2 open reading frame 78
chr12_-_53064565 0.222 ZNF385A
zinc finger protein 385A
chr17_+_23875085 0.221 NM_003593
FOXN1
forkhead box N1
chr2_+_48649662 0.219 NM_172311
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr6_+_142510034 0.218 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr14_-_23623657 0.218 NM_006177
NRL
neural retina leucine zipper
chr12_-_55316350 0.215 NM_013449
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr1_-_53972464 0.215 NM_147193
GLIS1
GLIS family zinc finger 1
chr6_-_138862273 0.209


chr2_+_1397186 0.208 NM_175721
NM_175722
TPO

thyroid peroxidase

chr8_-_124818754 0.206 NM_001003954
NM_004306
ANXA13

annexin A13

chr17_+_7563763 0.206 NM_020877
DNAH2
dynein, axonemal, heavy chain 2
chr2_-_87102453 0.204 NM_002665
NM_001032392
PLGLB2
PLGLB1
plasminogen-like B2
plasminogen-like B1
chr4_+_74491272 0.202 ALB
albumin
chr17_+_74542066 0.201 NM_198593
C1QTNF1
C1q and tumor necrosis factor related protein 1
chr6_+_155579788 0.199 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr12_+_53901075 0.198 NM_001005280
OR10A7
olfactory receptor, family 10, subfamily A, member 7
chr17_-_45626967 0.195


chr1_+_35020425 0.195 NM_001005752
GJB3
gap junction protein, beta 3, 31kDa
chr12_+_25096472 0.195 NM_006152
LRMP
lymphoid-restricted membrane protein
chr12_+_32546243 0.195 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr7_-_107667728 0.195 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr2_-_188021117 0.194 NM_005795
CALCRL
calcitonin receptor-like
chr9_+_115958051 0.192 NM_032888
COL27A1
collagen, type XXVII, alpha 1
chr11_-_85107569 0.187 NM_206929
SYTL2
synaptotagmin-like 2
chr11_+_117680504 0.185 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr2_-_74424041 0.185 NM_133478
SLC4A5
solute carrier family 4, sodium bicarbonate cotransporter, member 5
chr2_-_70374349 0.183 NM_003096
SNRPG
small nuclear ribonucleoprotein polypeptide G
chr6_-_10527772 0.180 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr2_+_33555182 0.178 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr11_+_61766299 0.177 NM_006551
SCGB1D2
secretoglobin, family 1D, member 2
chr10_+_7785331 0.177 ITIH2
inter-alpha (globulin) inhibitor H2
chr10_+_7785360 0.176 ITIH2
inter-alpha (globulin) inhibitor H2
chr14_+_50096492 0.176 NM_015915
NM_181598
ATL1

atlastin GTPase 1

chr1_+_242281199 0.175 ZNF238
zinc finger protein 238
chr1_-_205012348 0.175 NM_000572
IL10
interleukin 10
chr17_-_36347197 0.172 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr2_-_70374284 0.172 SNRPG
small nuclear ribonucleoprotein polypeptide G
chr1_-_172199799 0.171 RC3H1
ring finger and CCCH-type domains 1
chr6_-_29163027 0.171 NM_001005226
OR2B3
olfactory receptor, family 2, subfamily B, member 3
chr20_+_42644633 0.170 PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chrX_+_135106578 0.168 NM_001159701
NM_001159699
FHL1

four and a half LIM domains 1

chr10_+_7785290 0.165 ITIH2
inter-alpha (globulin) inhibitor H2
chr12_+_8216416 0.165 NM_001004328
ZNF705A
zinc finger protein 705A
chr10_+_7785347 0.164 ITIH2
inter-alpha (globulin) inhibitor H2
chr19_+_43502360 0.163 KCNK6
potassium channel, subfamily K, member 6
chr16_+_22011362 0.163 NM_173615
VWA3A
von Willebrand factor A domain containing 3A
chr4_+_186587537 0.161 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr12_+_26003218 0.160 NM_001164748
NM_007211
RASSF8

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

chr1_+_24518398 0.159 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr19_+_14913298 0.159 NM_012377
OR7C2
olfactory receptor, family 7, subfamily C, member 2
chr1_+_26358097 0.158 NM_024869
GRRP1
glycine/arginine rich protein 1
chr8_-_125785611 0.158 MTSS1
metastasis suppressor 1
chr2_+_238432925 0.157 NM_005855
RAMP1
receptor (G protein-coupled) activity modifying protein 1
chr12_+_99391870 0.156 NR1H4
nuclear receptor subfamily 1, group H, member 4
chr19_+_43502301 0.156 NM_004823
KCNK6
potassium channel, subfamily K, member 6
chr2_-_88208650 0.155 NM_001443
FABP1
fatty acid binding protein 1, liver
chr10_+_24538094 0.153 KIAA1217
KIAA1217
chr1_+_113064711 0.153 NM_001004440
NM_182759
FAM19A3

family with sequence similarity 19 (chemokine (C-C motif)-like), member A3

chr3_-_9266251 0.152 NM_001033117
NM_014850
SRGAP3

SLIT-ROBO Rho GTPase activating protein 3

chr19_-_58086410 0.151 NM_207333
ZNF320
zinc finger protein 320
chr1_+_85300580 0.150 NM_145172
WDR63
WD repeat domain 63
chr2_+_121271336 0.149 NM_005270
GLI2
GLI family zinc finger 2
chr6_+_142510075 0.149 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr7_-_7724762 0.146 NM_002947
RPA3
replication protein A3, 14kDa
chr19_-_9074981 0.145 NM_001005193
OR7G2
olfactory receptor, family 7, subfamily G, member 2
chr11_+_1817294 0.145 NM_001145829
TNNI2
troponin I type 2 (skeletal, fast)
chr6_+_142510094 0.140 NM_016485
VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr1_+_67404756 0.137 NM_144701
IL23R
interleukin 23 receptor
chr11_+_120478584 0.136 NM_005422
TECTA
tectorin alpha
chr3_-_115826481 0.136 NM_001164346
ZBTB20
zinc finger and BTB domain containing 20
chr12_-_66905802 0.136 NM_018402
IL26
interleukin 26
chr5_+_173405343 0.135 HMP19
HMP19 protein
chr19_-_14771947 0.134 NM_198944
OR7C1
olfactory receptor, family 7, subfamily C, member 1
chr16_-_31054321 0.133 PRSS8
protease, serine, 8
chr9_-_34719463 0.133 NM_001141917
C9orf144B
transmembrane protein C9orf144B
chr4_-_100359353 0.132 NM_000672
NM_001102470
ADH6

alcohol dehydrogenase 6 (class V)

chr20_+_57199469 0.131 NM_178457
ZNF831
zinc finger protein 831
chr17_-_34262862 0.130 RPL23
ribosomal protein L23
chr5_-_156468571 0.127 HAVCR2
hepatitis A virus cellular receptor 2
chr5_-_59819642 0.127 NM_001165899
PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_+_115455579 0.127 NCRNA00173
non-protein coding RNA 173
chr5_+_131424245 0.126 NM_000588
IL3
interleukin 3 (colony-stimulating factor, multiple)
chr1_-_201321711 0.125 MYOG
myogenin (myogenic factor 4)
chr17_+_41278035 0.125 NM_175882
IMP5
intramembrane protease 5
chr11_-_16454493 0.124 NM_033326
SOX6
SRY (sex determining region Y)-box 6
chr2_-_188127294 0.123 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr1_-_246789396 0.123 NM_001004694
OR2T29
OR2T5
olfactory receptor, family 2, subfamily T, member 29
olfactory receptor, family 2, subfamily T, member 5
chr4_+_120276386 0.123 NM_016599
MYOZ2
myozenin 2
chrX_+_15435351 0.123 NM_001721
BMX
BMX non-receptor tyrosine kinase
chrX_+_69371229 0.123 NM_001013579
AWAT1
acyl-CoA wax alcohol acyltransferase 1
chr14_+_22059174 0.122


chr6_+_123142559 0.121 FABP7
fatty acid binding protein 7, brain
chr17_+_55269974 0.121


chr2_-_224612177 0.118 NM_001136528
NM_006216
SERPINE2

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

chr2_+_161701711 0.117 NM_004180
NM_133484
TANK

TRAF family member-associated NFKB activator

chr16_-_15741438 0.117 MYH11
myosin, heavy chain 11, smooth muscle
chr13_-_42464301 0.117 NM_001002264
NM_033255
EPSTI1

epithelial stromal interaction 1 (breast)

chr17_+_76988134 0.116 NM_001080519
BAHCC1
BAH domain and coiled-coil containing 1
chr15_-_21444085 0.115 NM_019066
MAGEL2
MAGE-like 2
chr14_+_64041257 0.114 ZBTB1
zinc finger and BTB domain containing 1
chr11_+_111294868 0.113 C11orf52
chromosome 11 open reading frame 52
chr19_+_43502380 0.113 KCNK6
potassium channel, subfamily K, member 6
chr12_-_53064723 0.113 NM_015481
ZNF385A
zinc finger protein 385A
chr2_-_56266408 0.113 LOC100129434
hypothetical LOC100129434
chr6_-_29451042 0.112 NM_030959
OR12D3
olfactory receptor, family 12, subfamily D, member 3
chr3_-_33675484 0.112 CLASP2
cytoplasmic linker associated protein 2
chr8_-_17599438 0.112 NM_020749
MTUS1
microtubule associated tumor suppressor 1
chr5_+_140848905 0.111 NM_018929
NM_032407
PCDHGC5

protocadherin gamma subfamily C, 5

chr3_-_150578103 0.111 TM4SF1
transmembrane 4 L six family member 1
chr5_+_173405298 0.111 NM_015980
HMP19
HMP19 protein
chr20_-_1321571 0.111 FKBP1A
FK506 binding protein 1A, 12kDa
chr18_+_27152049 0.111 NM_001942
DSG1
desmoglein 1
chr20_-_43601542 0.111 NM_080827
WFDC6
WAP four-disulfide core domain 6
chr19_-_6671585 0.110 NM_000064
C3
complement component 3
chr6_+_142510108 0.109 VTA1
Vps20-associated 1 homolog (S. cerevisiae)
chr7_-_92585253 0.109 NM_001193307
NM_017654
SAMD9

sterile alpha motif domain containing 9

chr5_+_38881719 0.108 NM_003999
OSMR
oncostatin M receptor
chr12_+_439803 0.107 NM_173593
B4GALNT3
beta-1,4-N-acetyl-galactosaminyl transferase 3
chr9_-_14076901 0.107 NFIB
nuclear factor I/B
chr12_-_55920741 0.103 NM_020142
NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr4_+_14985272 0.102 NM_001135171
C1QTNF7
C1q and tumor necrosis factor related protein 7
chr12_+_51931636 0.102 NM_001170790
MFSD5
major facilitator superfamily domain containing 5
chr6_-_133076873 0.102 NM_004666
VNN1
vanin 1
chr7_-_92585205 0.102 SAMD9
sterile alpha motif domain containing 9
chr11_+_111294810 0.102 NM_080659
C11orf52
chromosome 11 open reading frame 52
chr8_+_11388918 0.101 NM_001715
BLK
B lymphoid tyrosine kinase
chr7_+_91762227 0.101


chr3_-_150578148 0.100 TM4SF1
transmembrane 4 L six family member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.98 1.71e-04 GO:0007608 sensory perception of smell
2.66 1.82e-03 GO:0007606 sensory perception of chemical stimulus

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.69 2.00e-03 GO:0031012 extracellular matrix
1.91 3.34e-03 GO:0044421 extracellular region part
2.67 1.15e-02 GO:0005578 proteinaceous extracellular matrix
1.35 1.64e-02 GO:0071944 cell periphery
1.53 2.77e-02 GO:0005576 extracellular region

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.12 1.26e-05 GO:0004984 olfactory receptor activity
1.76 1.19e-02 GO:0004888 transmembrane receptor activity
1.92 2.41e-02 GO:0004930 G-protein coupled receptor activity